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pentobarbital will lower the level or influence of alfentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.pentobarbital will minimize the level or outcome of duvelisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with a powerful CYP3A ind